In order to enhance or extend drug absorption, drug sustained-release has been extensively studied. SPR can compare the sustained release of different drugs in situ.
The advantage of SPR in the study of drug sustained release:
1. Release drugs from micron scale samples
2. Real time label free detection
3. Study the structural changes
4. The rate of drug release from the material can be studied
Reference:
Interaction studies between indomethacin nanocrystals and PEO/PPO copolymer stabilizers, Liu et al., Pharmaceutical Research, 2015
